From my understanding, i thought that because of the strategic location of the klatskin tumor, it can cause obstruction and hence an earlier presentation by the patient with jaundice and thus. It poses unique problems in the diagnosis and management because of. Endoscopic palliative therapy allowed a faster community reintegration, but with variable evolution. A klatskin tumor or hilar cholangiocarcinoma is a cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left hepatic bile ducts. Fiftytwo patients who had undergone resection of a klatskin tumor were divided into two groups. Bile duct cancer klatskin tumor see bile duct cancer procedure.
Mcqs mcqs mcqs mcqs mcqs mcqs mcqs mcqs mcqs mcqs pdf reader. A, longitudinal view of the common hepatic duct shows a tapered segment arrow consistent with tumor stricture. Download fullsize image gerald klatskin 19101986 was born in new york city to a family of russian descent. Extent of liver resection for hilar cholangiocarcinoma klatskin. Bile duct cancer klatskin tumor liver and pancreas surgeon. Klatskin tumors are rare, malignant tumors of the biliary system with a poor prognosis for patient survival. Endoscopic retrograde cholangiopancreatography and. Prior medical history showed diabetes mellitus type i, high blood pressure, and deep vein thrombosis. Survival and quality of life of cholangiocarcinoma. During his undergraduate years at cornell he developed a keen.
Klatskin tumor is a term that was traditionally given to a hilar cholangiocarcinoma, occurring at the bifurcation of the common hepatic duct. This is the least common form of the disease, accounting for less than 10 percent of all cases. Surgical strategies in the management of hilar cholangiocarcinoma. A klatskin tumor is a tumor which forms in the upper region of the bile duct, where the left and right bile ducts meet. Hilar cholangiocarcinoma known also as klatskin tumor accounts for more than a half. Hiliar cholangiocarcinoma is the most common type of cholangiocarcinoma, an represent around 10% of all. There is prooved connection between this malignant tumor and primary sclerosis cholangitis autoimmune disease and parasitic infection in biliary ducts clonorchis sinensis and opisthorchis viverrini, both in southeast asia.
Named after gerald klatskin, who described a number of cases in 1965. There is prooved connection between this malignant tumor and primary sclerosis cholangitis autoimmune disease and. Therapeutical concepts and results for klatskin tumors. Best biliary drainage option in advanced klatskin tumor. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior, and tend to obstruct the intrahepatic bile ducts. Klatskin tumor hilar cholangiocarcinoma or central bile duct carcinoma, kcc is a rare type of tumor, with an annual incidence of no more than 1. Klatskin tumor listen klatskin toomer cancer that develops in cells that line the bile ducts in the liver, where the right and left ducts meet. Endoscopic retrograde cholangiopancreatography and endoscopic endoprosthesis insertion have a limited value in the management of patients with klatskin tumors.
Her problems started about three weeks ago when she felt dizzy and had. The clinical picture of prostatic cancer is sometimes puzzling, partly because of the marked variation in the pattern of dissemination 1. Curative treatment of klatskin tumors by radical surgical procedures with surgical preparation distant to the tumor region results in 5year survival rates of 3050%. Although surgical resection is the treatment of choice if possible, the prognosis. A klatskin tumor is a cholangiocarcinoma that arises at near. In the left and right biliary system wires were placed. In 73 of the resected patients 67%, all gross tumor was removed, while in 36 patients 33% gross tumor was left behind after resection. Both parts were injected through a tube with contrast. Perihilar bile duct tumors can be further classified as type 1 through type 4. Any information contained in this pdf file is automatically generated from. Hilar cholangiocarcinoma klatskin tumor 117 showed no pulmonary parenchymal or pleural eff usion. The lack of contrast in the area of the confluence is. Klatskin tumor is known to be highly resistant to conventional chemotherapy and radiotherapy.
I live in north carolina and i was told that i had a rare but not unheard of cancer which was klatskin tumor on. I dont know if you are still fighting klatskin,but there is hope. Hilar cholangiocarcinoma hc comprises up to 5070 % of all. Abdominal ct scans showed neither liver compromise nor compromise of the lymph. While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a small percentage of those diagnosed because they are known to cause biliary inflammation and may be related to klatskin tumor formation primary sclerosing cholangitis. A, longitudinal view of the common hepatic duct shows a tapered segment arrow. Intrahepatic cholangiocarcinoma begins in the small bile ducts within the liver. Surgical treatment of hilar cholangiocarcinoma hcca has shifted from local excision of. Klatskin tumor, or hilar cca involving the bifurcation of the hepatic duct, accounts for approximately 60 % of all bile duct cancers and is the second most common primary malignant. Sonographic features of these tumors include a dilatation of the intrahepatic biliary ducts but. Once the diagnosis of klatskin tumor was confirmed on cholangiogram, endoscopic stenting was performed to bypass the stricture. Klatskin tumor synonyms, klatskin tumor pronunciation, klatskin tumor translation, english dictionary definition of klatskin tumor. Cholangiocarcinoma staging is dependent on whether the tumor is primarily intrahepatic icc, hilarperihilar klatskin, or extrahepatic tumor resection is currently the most optimal.
Klatskinlike lesions hindawi publishing corporation. Another classification groups biliary tract cancers as intrahepatic, perihilar and distal extrahepatic. Klatskin tumor genetic and rare diseases information. All types of cancerous growth in the biliary duct are termed as cholangiocarcinoma. Klatskin tumor is a type of cancerous growth develops at the junction between right and left biliary duct from where main bile duct is formed. Klatskin tumor definition of klatskin tumor by the free. Klatskin tumor patients than in patients with other types of tumors.
Hilar cholangiocarcinoma, also known as klatskin tumour, is the commonest type of cholangiocarcinoma. The authors present 3 cases of surgically proved klatskin tumor diagnosed by ultrasound alone. Longterm outcomes of intraductal photodynamic therapy in klatskin. A 60yearold male patient presented with painless jaundice. Klatskin tumor definition of klatskin tumor by medical.
Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. Symptoms usually dont present until advanced stages of disease, when jaundice is the most common feature. The proximal extent of tumor into the intrahepatic biliary tree largely determines local resectability of hcca. Igg4related sclerosing cholangitis mimicking hilar. Klatskin tumors classically manifest as segmental dilatation and nonunion of the right and left ducts at the porta hepatis. Liver function is impaired as a result of cholestasis, and this is an important risk factor in large liver resections. Cholangiocarcinoma involving the hepatic bifurcation are categorized as hilar bile duct cancer or klatskin tumors. It is the most common type of cholangiocarcinoma, accounting for more than half of all cases. Pdf diagnosis and management of klatskin tumor researchgate. Kat not real name is a 64yearold indonesian lady from aceh.
Pdf nomograms predict survival outcome of klatskin. While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a. A case of inoperable klatskin tumor showing response to. I will be having an ercp this friday to get a biopsy and see how much blockage there is. Pdf on jan 1, 2016, daniel v kostov and others published klatskin tumors find, read and cite all the research you need on. Klatskin tumor article about klatskin tumor by the free.
Klatskin tumor plural klatskin tumors cholangiocarcinoma at the confluence of. Cholangiocarcinoma staging radiology reference article. In recent years, with the invention and development of the technology of mdct, increasing numbers of reports have been published on its use for preoperative assessment of liver tumors. Definition of klatskin tumor nci dictionary of cancer. Preoperative evaluation of resectability of klatskin tumor. Klatskin tumor is quite rare, more in male sex in age 60 years. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The disease was named after gerald klatskin, who in 1965 described 15 cases and found some characteristics for this type of cholangiocarcinoma. Most relevant publications describing the resection of klatskin tumors. Among this almost 60% to 70 % biliary duct cancer is klatskin tumor 1,2.
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